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Free health research portals

• Fibromyalgia
• Central sensitisation
• Long COVID and ME/CFS
• ADHD
• Arthritis
• Multiple sclerosis
• Arachnoiditis

Science Made Usable

• Cortisol Is Called the Stress Hormone. It Is Really a Fuel Hormone - and It Makes Fuel by Taking Your Muscle Apart.

  Cortisol does not give you energy. It dismantles part of your body to make some - pulling amino acids from muscle and fat from fat stores so your liver can build new glucose. That single fact explains the 3pm slump, the 3am wake-up after drinking, why under-eating raises it, and why the goal is the shape of the curve, not a lower number.

• The Ache Two Days After a Hard Workout Is Not Coming From Your Muscles

  Sixteen people were injected with the same irritant twice - once into muscle, once into the fascia on top of it. The fascia injection hurt 86% more at peak, lasted up to twice as long and spread across an area 65% larger. No standard scan assesses this tissue. Here is what fascia actually is, why foam rolling does not do what you were told, and what genuinely changes it.

• Your Brain Does Not Take Your Word For It. It Keeps a Record of You.

  Your brain has been gathering data on you your whole life, and it believes the data over the promises. That is why big intentions fail and irrationally small kept promises work. It is also why chronic illness damages self-trust so badly - and why pacing beats pushing.

• The Panic You Feel in Your Head Is Not Adrenaline. Adrenaline Cannot Get Into Your Brain at All.

  Adrenaline never reaches your brain. Neither do circulating endorphins. Dopamine fires hardest before you get the thing, not after. Ninety percent of your serotonin is in your gut. Here is what each of the ten major molecules genuinely does, where it is produced, and why the popular version of brain chemistry gets the anatomy wrong.

• Nature Has Been Making Painkillers for Millions of Years. Here Is the Actual Chemistry Inside Them.

  Eugenol in cloves is a real local anaesthetic. Salicin in willow bark is what aspirin was built from. Every item on this list contains a compound we can name, measure and study - which is exactly why they can help you and why they can interact with your medication. Here is what each one is actually good for.

• There Is a Muscle at the Base of Your Skull That Is Physically Attached to the Covering of Your Brain

  Rectus capitis posterior minor connects through a gap in the bone to the dura mater that wraps your brain and spinal cord. The neck and the head were never two separate problems. Here is how a cervicogenic headache behaves, the one-minute test that identifies it, why it gets felt behind an eye, and the trial evidence that it responds to treatment.

• Your Brain Has a Volume Control for Pain. In Chronic Pain, It Can Get Stuck Turned Up.

  Pathways run from your brainstem into your spinal cord and set how much of a signal gets through. They can suppress it - which is why an athlete finishes the match and finds the injury afterwards. The same circuitry can amplify. Here is the neuroscience of descending facilitation, central sensitisation, and why understanding the mechanism is itself one of the best-evidenced treatments we have.

• You Have a Floating Bone in Your Throat. Around It Sits a Control Panel for Your Nervous System.

  The hyoid is the only bone in your body that does not articulate with another. Around it converge five cranial nerves. One of them is the vagus. This is why your breath, your exhale, your voice and your swallow can genuinely shift your physiological state - not by suggestion, but through anatomy.

Recalibrate is an education and self-tracking tool, not a diagnostic service or a replacement for medical care.